Heteroaryl carboxamides

Details Heteroaryl carboxamides Heteroaryl carboxamides

C - Chemistry, Metallurgy

07

D

C07D 215/48 (2006.01) A61K 31/47 (2006.01) A61K 31/517 (2006.01) A61P 25/28 (2006.01) C07D 241/46 (2006.01) C07D 453/02 (2006.01)

Patent

CA 2467367

The invention relates to novel heteroaryl carboxamides of formula (I) and salts, hydrates or solvates thereof, processes for their preparation, and their use for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory. (see formula I) In formula (I), R1 is an azabicyclo[m.n.o]alkyl radical having 7 to 11 ring atoms, in which m, n and o are identical or different and are 0, 1, 2 or 3, and where the radical is optionally substituted by (C1-C6)-alkyl; the ring A is pyrimido, or is optionally benzo-fused pyrido, pyridazo or pyrazino; and R2 and R3 are identical or different radicals, wherein the radical is hydrogen, halogen, formyl, carbamoyl, cyano, trifluoromethyl, trifluoromethoxy, nitro, (C1-C6(-alkyl, (C1-C6)- alkoxy, (C1-C6)-alkylthio, (C3-C8)-cycloalkyl, 4- to 8-membered heterocyclyl, phenyl or 5- to 6-membered heteroaryl, where phenyl and heteroaryl are optionally substituted by halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, amino, mono- or di-(C1-C4)- alkylamino, (C1-C4)-alkanoylamino or (C1-C4)-alkanesulfonylamino.

L'invention concerne de nouveaux amides d'acide hétéroarylcarboxylique, leur procédé de production et leur utilisation pour produire des médicaments permettant de traiter et/ou de prévenir des maladies et améliorer la perception, la concentration, la capacité d'apprentissage et/ou la mémoire.

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