C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/04 (2006.01) A61K 31/4184 (2006.01) A61K 31/4245 (2006.01) A61K 31/4427 (2006.01) A61K 31/4439 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61K 31/52 (2006.01) C07D 235/18 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 409/04 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2475633
The present invention relates to compounds of formula I wherein: Ring A is an optionally substituted 5-7 membered, partially unsaturated or fully unsaturated ring having 0-3 heteroatoms independently selected from nitrogen, oxygen or sulfur, and wherein Ring A is optionally fused to an optionally substituted saturated, partially unsaturated or fully unsaturated 5-8 member ring having 0-3 heteroatoms independently selected from nitrogen, oxygen or sulfur; Ring B is an optionally substituted 5-6 membered ring having 0 to 4 heteroatoms, independently selected from nitrogen, oxygen, or sulfur, wherein said ring has a first substituent, -N(R1)2, in the position adjacent to the point of attachment, and is optionally substituted by up to two additional substituents. Compoounds of formula I are useful as inhibitors of GSK-3 and Lck protein kinases. The present invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes, Alzheimer~s disease, and transplant rejection.
La présente invention concerne des composés de formule I utiles en tant qu'inhibiteurs de protéines kinases GSK-3 et Lck. La présente invention concerne également des compositions pharmaceutiquement acceptables comprenant lesdits composés de l'invention et des méthodes d'utilisation desdites compositions dans le traitement et la prévention de divers troubles, tels que le diabète, la maladie d'Alzheimer et le rejet de greffe.
Arnost Michael J.
Green Jeremy
Harbeson Scott L.
Savic Vladimir
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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