C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61P 3/10 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2543239
This invention relates to compounds of formula (I), wherein one of R6, R7 and R8 is formula (II) and X, Y1 to Y4 , R1 to R 14 and n are as defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR.delta. and/or PPAR.alpha. agonists.
La présente invention concerne des composés de formule (I) dans laquelle R?6¿, R?7¿ et R?8¿ sont représentés par la formule (II), et X, Y?1¿ à Y?4¿ , R?1¿ à R ?14¿ et n sont tels que définis dans la description, et des énantiomères totaux et des sels et/ou esters pharmaceutiquement acceptables de ceux-ci. L'invention a également pour objet des compositions pharmaceutiques contenant ces composés, un procédé pour les préparer et leur utilisation pour traiter et/ou prévenir des maladies qui sont modulées par des agonistes de PPAR.delta. et/ou de PPAR.alpha..
Ackermann Jean
Aebi Johannes
Binggeli Alfred
Grether Uwe
Hirth Georges
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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