Heteroaryl diazacycloalkanes, their preparation and use

Details Heteroaryl diazacycloalkanes, their preparation and use Heteroaryl diazacycloalkanes, their preparation and use

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/495 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2367695

The present invention relates to novel heteroaryl diazacycloalkane derivatives which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

La présente invention porte sur de nouveaux dérivés d'hétéroaryl diazacycloalkane qui s'avèrent être des ligands cholinergiques au niveau des récepteurs nicotiniques de l'acétylcholine. En raison de leur profil pharmacologique, les composés de l'invention peuvent être utilisés dans le traitement de maladies ou troubles aussi divers que ceux relatifs au système cholinergique du système nerveux central (CNS), de maladies ou troubles relatifs à la contraction des muscles lisses, de maladies ou troubles endocriniens, de maladies ou troubles relatifs à la neurodégénération, de maladies ou troubles relatifs à l'inflammation, la douleur et les symptômes de sevrage provoqués par l'arrêt de l'emploi abusif de substances chimiques.

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