Heteroaryl diol acids as leukotriene antagonists

Details Heteroaryl diol acids as leukotriene antagonists Heteroaryl diol acids as leukotriene antagonists

C - Chemistry, Metallurgy

07

D

C07D 215/18 (2006.01) A61K 31/4365 (2006.01) A61K 31/47 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2223414

Compounds of formula (I) are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti--allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.

L'invention se rapporte à des composés antagonistes des leucotriènes, qui sont représentés par la formule (I). Ces composés sont utiles comme agents anti-asmathiques, anti-allergiques, anti-inflammatoires et cytoprotecteurs. Ils sont également utiles dans le traitement de l'angine de poitrine, des spasmes cérébraux, de la glomérulonéphrite, de l'hépatite, de l'endotoxémie, de l'uvéité et du rejet d'allogreffes.

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