Heteroaryl-fused pyrimidinyl compounds as anticancer agents

Details Heteroaryl-fused pyrimidinyl compounds as anticancer agents Heteroaryl-fused pyrimidinyl compounds as anticancer agents

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2526217

Heteroaryl-fused pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the heteroaryl-fused pyrimidinyl compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the heteroaryl-fused pyrimidinyl compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.

L'invention concerne des composés de pyrimidinyle accolés à un hétéroaryle, des sels acceptables d'un point de vue pharmaceutique et des promédicaments de ceux-ci, et des compositions contenant un excipient acceptable d'un point de vue pharmaceutique et un ou plusieurs composés de pyrimidinyle accolés à un hétéroaryle, seuls ou combinés à au moins un agent thérapeutique supplémentaire. L'invention concerne également des méthodes d'utilisation desdits composés de pyrimidinyle accolés à un hétéroaryle, seuls ou combinés à au moins un agent thérapeutique, dans la prophylaxie ou le traitement des maladies prolifératives.

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