Heteroaryl-hydrazone compounds

Details Heteroaryl-hydrazone compounds Heteroaryl-hydrazone compounds

A - Human Necessities

61

K

A61K 31/497 (2006.01) A61K 31/5377 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2545259

This invention relates to compounds having a formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, hydrate, prodrug or polymorph thereof wherein X is -C(Rg)=N-A. The invention also relates to methods of treating IL-12 verproduction-related disorders, methods of treating or preventing disorders related with excessive bone loss, methods for inhibiting osteoclast formation, and methods for treating or preventing a disorder associated with excessive bone resorption.

L'invention concerne des composés de formule (I), dans laquelle X est C(R?g¿)=N-A, ou un sel pharmaceutiquement acceptable, un solvate, un clathrate, un hydrate, un promédicament ou un polymorphe de ces composés. L'invention concerne également des méthodes destinées à traiter les troubles associés à la surproduction d'IL-12, des méthodes de traitement ou de prévention de troubles associés à une perte osseuse excessive, des méthodes destinées à inhiber la formation d'ostéoclastes, ainsi que des méthodes destinées à traiter ou prévenir un trouble associé à une résorption osseuse excessive.

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