Heteroaryl piperidine glycine transporter inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/04 (2006.01) A61K 31/4545 (2006.01) A61K 31/497 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2560256

The present invention is directed to pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction and diseases in which the glycine transporter GlyT1 is involved.

La présente invention concerne des composés de pyridyle, pyridazinyle, pyrimidinyle et pyrazinylpipéridine, inhibant le transporteur de glycine GlyT1 et utiles dans le traitement de troubles neurologiques et psychiatriques associés au dysfonctionnement de la neurotransmission glycinergique ou glutamatergique et de maladies dans lesquelles le transporteur de glycine GlyT1 est impliqué.

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