Heteroaryl quinolines as inhibitors of leukotriene biosynthesis

Details Heteroaryl quinolines as inhibitors of leukotriene biosynthesis Heteroaryl quinolines as inhibitors of leukotriene biosynthesis

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/395 (2006.01) A61K 31/70 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 491/048 (2006.01) C07D 493/08 (2006.01) C07D 495/04 (2006.01) C07H 15/04 (2006.01)

Patent

CA 2167317

Compounds having formula (I) are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti- anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular, nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic, plaques.

L'invention concerne des composés de la formule (I), inhibiteurs de la biosynthèse des leucotriènes. Ces composés sont utiles comme agents antiasthmatiques, antiallergiques, antiinflammatoires et cytoprotecteurs. Ils sont également utiles dans le traitement d'angines, de spasmes cérébraux, de la glomérulonéphrite, d'hépathites, d'endotoxémies, de l'uvéite et de rejets d'allogreffes, ainsi que dans la prévention de la formation de plaques athéroscléreuses.

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