Heteroaryl-substituted alkyne compounds and method of use

Details Heteroaryl-substituted alkyne compounds and method of use Heteroaryl-substituted alkyne compounds and method of use

C - Chemistry, Metallurgy

07

D

C07D 239/42 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2583907

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I: wherein A1, A2, A3, A4, R1 and R2 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.

La présente invention concerne une nouvelle classe de composés convenant à la prophylaxie et le traitement d'affections à médiation par les protéine-kinases, et notamment l'inflammation, le cancer et les états associés. Ces composés sont représentés par une formule générale (I) dans laquelle A1, A2, A3, A4, R1 et R2 sont tels que définis dans la présente demande. L'invention concerne également, d'une part des compositions pharmaceutiques comprenant les composés de l'invention, des procédés permettant, grâce aux composés et compositions de l'invention, la prophylaxie et le traitement de maladies à médiation par les kinases, et d'autre part des intermédiaires et des procédés convenant à l'élaboration des composés de l'invention.

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