Heteroaryl-substituted bicyclic smac mimetics and the uses...

Details Heteroaryl-substituted bicyclic smac mimetics and the uses... Heteroaryl-substituted bicyclic smac mimetics and the uses...

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) C07D 235/06 (2006.01) C07D 403/02 (2006.01)

Patent

CA 2725398

The invention relates to heteroaryl-substituted bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.

Linvention concerne des substances mimétiques de Smac bicycliques substituées par hétéroaryle qui fonctionnent comme des inhibiteurs dinhibiteur de protéine dapoptose. Linvention concerne également dutilisation de ces substances mimétiques pour induire une mort cellulaire apoptotique et pour sensibiliser les cellules à des inducteurs dapoptose.

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