C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/231, 260/273
C07D 471/04 (2006.01) A61K 31/44 (2006.01)
Patent
CA 2025084
8676N ABSTRACT 5-Substituted Heterocyclic Imidazopyridines This invention relates to substituted imidazopyridine derivatives having the following formula Image or a pharmaceutically acceptable acid addition salt thereof: wherein ? ? ? ? R1 and R2 are each independently selected from hydrogen; straight or branched chain alkyl of 1 to 15 carbon atoms; cycloalkyl of 3 to 8 carbon atoms; substituted cycloalkyl which can be substituted one or more by alkyl of 1 to 6 carbon atoms; phenyl; substituted phenyl which can be substituted one or more by alkyl of 1 to 6 8676N carbon atoms or halogen; straight or branched alkenyl having 3 to 15 carbon atoms with the proviso that the double bond of the alkenyl group cannot be adjacent to the nitrogen. Het is a heteroaromatic ring having 5 atoms wherein said atoms are selected from carbon, nitrogen, oxygen or sulfur and wherein any of the carbon atoms can be optionally substituted with a substituent independently selected from the group consisting of alkyl of 1 to 6 carbon atoms, alkoxy wherein the alkyl is 1 to 6 carbon atoms and halogen selected from bromo, fluoro, or chloro with the proviso that the carboxamide and imidazopyridine groups cannot be ortho to each other and a nitrogen hetero atom of the heteroaryl ring is substituted by hydrogen or alkyl of 1 to 6 carbon atoms or 8676N a heteroaromatic ring having 6 atoms whereine said atoms are selected from carbon and nitrogen and wherein any of the carbon atoms can be optionally substituted with a substituent independently selected from the group consisting of alkyl of 1 to 6 carbon atoms; alkoxy wherein the alkyl is 1 to 6 carbon atoms and halogen selected from bromo, fluoro or chloro with the proviso that the carboxamide and imidazopyridine groups cannot be ortho to each other. n is an integer from 1 to 5. R3 is a group substituted at one or more of the 4, 6 or 7 positions of the pyridine ring said group being independently selected from hydrogen, alkyl of 1 to 6 carbon atoms; halogen wherein the halogen is selected from bromo, fluoro, or chloro; of alkoxy wherein the alkyl is 1 to 6 carbon atoms. 8676N R4 is hydrogen or alkyl of 1 to 4 carbon atoms. useful in the treatment of diseases or disorders mediated by platelet-activating factor. This invention also relates to pharmaceutical compositions of such substituted imidazopyridines.
Khanna Ish K.
Weier Richard M.
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
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