C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61P 25/28 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2527587
The present invention relates to imidazole derivatives of the general formula (I) wherein R1, R2, R3 and R4 are as defined in the specification as well as to pharmaceutically acceptable salts thereof and to processes for the preparation thereof. The invention also relates to the use of said imidazole derivatives for the preparation of medicaments and to medicaments containing them for the prevention or the treatment of mGluR5 receptor mediated disorders, such as acute and/or chronic neurological disorders, in particular anxiety, or for the treatment of chronic and acute pain.
L'invention concerne des dérivés d'imidazoles de formule générale (I) dans laquelle R?1¿, R?2¿, R?3¿ et R?4¿ ont la même définition que dans la spécification, ainsi que des sels pharmaceutiquement acceptables desdits composés et des processus de préparation correspondants. L'invention concerne également l'utilisation desdits dérivés d'imidazoles dans la préparation de médicaments, ainsi que des médicaments les contenant, utilisés dans la prévention et le traitement de troubles induits par le récepteur de mGluR5, tels que des troubles neurologiques aigus et/ou chroniques, notamment l'anxiété, ou dans le traitement de douleurs chroniques et aiguës.
Buettelmann Bernd
Ceccarelli Simona Maria
Jaeschke Georg
Kolczewski Sabine
Porter Richard Hugh Philip
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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