C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4439 (2006.01) C07D 209/30 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2470612
Imidazole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorder and panic, as well as in the treatment of pain, circadian rhythm disorders, and other diseases.
La présente invention concerne des composés d'imidazole substitué, directement ou au moyen d'un pont, par un fragment hétéroaryle contenant un N adjacent au point de connexion de l'hétéroaryle, lesquels composés sont des modulateurs du mGluR5 et sont utilisés dans le traitement de troubles psychiatriques et de l'humeur tels que, par exemple, la schizophrénie, l'anxiété, la dépression, les troubles bipolaires et les troubles paniques, de même que dans le traitement de la douleur, des troubles du rythme circadien et autres maladies.
Cosford Nicholas D. P.
Huang Dehua
Smith Nicholas D.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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