C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/422 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/495 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01)
Patent
CA 2469813
Pyrazole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorder and panic, as well as in the treatment of pain, circadian rhythm disorders, and other diseases.
L'invention concerne des composés de pyrazole substitués directement, ou au moyen d'un pont, par un groupe fonctionnel hétéroaryle contenant N dans une position adjacente au point de liaison de l'hétéroaryle. Ces composés sont des modulateurs mGluR5 utilisés dans le traitement des troubles psychiatriques et des troubles de l'humeur, tels que la schizophrénie, l'angoisse, la dépression, le trouble bipolaire et la panique, et dans le traitement de la douleur, des troubles du rythme circadien et d'autres maladies.
Chen Chixu
Cosford Nicholas D. P.
Eastman Brian W.
Huang Dehua
Munoz Benito
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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