Heteroaryl substituted pyrrolo[2,3-b]pyridines and...

Details Heteroaryl substituted pyrrolo[2,3-b]pyridines and... Heteroaryl substituted pyrrolo[2,3-b]pyridines and...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/395 (2006.01) A61P 17/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2632466

The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines (I) and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

La présente invention concerne des pyrrolo[2,3-b]pyridines substituées par des groupements hétéroaryle (I) et des pyrrolo[2,3-b]pyrimidines substituées par des groupements hétéroaryle destinées à moduler l~activité des kinases Janus et utiles pour le traitement de maladies liées à l~activité des kinases Janus, y compris, par exemple, les maladies immunologiques, les troubles dermatologiques, les troubles prolifératifs myéloïdes, les cancers et autres maladies.

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