C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 285/14 (2006.01) A61K 31/433 (2006.01) A61P 25/28 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2484159
Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
Cette invention porte sur les composés représentés par la formule (I) dans laquelle X désigne un noyau hétéroaryle à 5 chaînons et R est tel que défini dans la description. Ces composés sont des inhibiteurs du traitement de la protéine précurseur amyloïde (APP) par la gamma-sécrétase, et servent de ce fait au traitement de la maladie d'Alzheimer.
Collins Ian James
Cooper Laura Catherine
Harrison Timothy
Keown Linda Elizabeth
Madin Andrew
Merck Sharp & Dohme Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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