C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2688343
Certain heteroaryl-substituted piperidinyl and piperazinyl urea compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, insulin resistance, diabetes, osteoporosis, and movement disorders (e.g., multiple sclerosis).
L'invention concerne certains composés uréiques substitués hétéroaryle de pipéridinyle et pipérazinyle qui sont utiles en tant qu'inhibiteurs de la FAAH. De tels composés peuvent être utilisés dans des compositions pharmaceutiques et dans le cadre de méthodes de traitement de maladies, de troubles et de manifestations pathologiques induites par l'amide hydrolase d'acides gras, notamment l'anxiété, la douleur, l'inflammation, les troubles de sommeil, les troubles de l'alimentation, la résistance à l'insuline, le diabète, l'ostéoporose et les troubles moteurs (comme par exemple dans la sclérose en plaques).
Apodaca Richard
Breitenbucher J. Guy
Hawryluk Natalie A.
Jones William M.
Keith John M.
Janssen Pharmaceutica N.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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