Heteroaryl sulfonamides and ccr2

C - Chemistry – Metallurgy – 07 – D

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C07D 213/02 (2006.01) A61K 31/44 (2006.01) C07D 401/02 (2006.01)

Patent

CA 2594726

Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

La présente invention concerne des composés qui servent d'antagonistes puissants du récepteur CCR2. Des tests réalisés sur des animaux montrent que ces composés permettent de traiter des inflammations, une maladie caractéristique de CCR2. Les composés sont généralement des dérivés de sulfonamide d'aryle et sont utilisés dans des compositions pharmaceutiques, dans le cadre de méthode de traitement de maladies à médiation par CCR2 et comme témoins dans des dosages pour identifier des antagonistes de CCR2.

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