Heteroarylalkanoic acids as integrin receptor antagonists

Details Heteroarylalkanoic acids as integrin receptor antagonists Heteroarylalkanoic acids as integrin receptor antagonists

A - Human Necessities

61

K

A61K 31/4245 (2006.01) A61K 31/4745 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 27/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2507699

The present invention relates to pharmaceutical compositions comprising compounds of the Formula I, or a pharmaceutically acceptable salt thereof, and methods of selectively inhibiting or antagonizing the .alpha..nu..beta.3 and/or the .alpha..nu..beta.5 integrin without significantly inhibiting the .alpha..nu..beta.6 integrin.

La présente invention a trait à des compositions pharmaceutiques comprenant des composés de formule (I), ou un sel pharmaceutiquement acceptable de celui-ci, et des procédés d'inhibition ou d'antagonisation sélective de .alpha.¿v?.beta.¿5? et/ou de l'intégrine .alpha.¿v?.beta.¿5? sans inhibition notable de l'intégrine .alpha.¿v?.beta.¿6?.

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