C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/175 (2006.01) A61K 31/395 (2006.01) A61K 31/42 (2006.01) C07D 231/12 (2006.01) C07D 261/08 (2006.01) C07D 261/18 (2006.01) C07D 277/32 (2006.01) C07D 401/12 (2006.01) C07D 413/02 (2006.01)
Patent
CA 2302438
The present invention relates to novel heteroarylcarboxamides which modulate the activity of protein tyrosine kinases and are expected to be useful in the treatment of abnormal protein tyrosine kinase activity driven disorders, to methods for the treatment of inappropriate FGFR activity related disorders with the heteroarylcarboxamide, N-(4-trifluoromethyl-phenyl)-5-methylisoxazole- 4-carboxamide, and to the treatment of solid tumor cancers, especially glioblastoma and astrocytoma, with a combination of a nitrosourea, preferably BCNU (carmustin) and N-(4-trifluoromethyl-phenyl)-5-methylisoxazole-4- carboxamide.
Nouveaux hétéroarylcarboxamides qui modulent l'activité des protéine tyrosine kinases et dont on pense qu'ils sont utiles dans le traitement d'états pathologiques dus à l'activité anormale des protéine tyrosine kinases, méthodes de traitement d'états pathologiques liés l'activité inappropriée des récepteurs de facteur croissance des fibroblastes (FGFR) à l'aide de l'hétéroarylcarboxamide N-(4-trifluorométhyl-phényl)-5-méthylisoxazole-4-carboxamide et traitement de cancers à tumeurs solides, en particulier le glioblastome et l'astrocytome, avec une combinaison de nitrosourée, de préférence BCNU (carmustine), et de N-(4-trifluorométhyl-phényl)-5-méthylisoxazole-4-carboxamide.
Hirth Klaus Peter
Mcmahon Gerald
Shawver Laura Kay
Tang Peng Cho
Smart & Biggar
Sugen Inc.
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