C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/242, 260/308
C07D 209/04 (2006.01) C07D 209/08 (2006.01) C07D 209/88 (2006.01) C07D 231/56 (2006.01) C07D 235/06 (2006.01) C07D 235/08 (2006.01) C07D 235/26 (2006.01) C07D 241/42 (2006.01) C07D 249/18 (2006.01) C07D 285/14 (2006.01)
Patent
CA 1203236
ABSTRACT The present invention provides heteroaryloxy- propanolamines of the general formula:- Image (I) wherein A is a bi- or tricyclic heteroaromatic radical, which is optionally partly hydrogenated, X is a straight- chained or branched alkylene chain containing 2 to 6 carbon atoms, R1 and R2, which can be the same or different, are hydrogen atoms or lower alkyl or benzyl radicals, R3, R4 and R5, which can be the same or different, are hydrogen atoms or lower alkyl, benzyl, formyl, lower alkanoyl, cyano, hydroxymethyl, lower alkoxycarbonyl or carbamoyl radicals or the divalent substituents sulphur or oxygen and R6, R7 and R8, which can be the same or different, are hydrogen or halogen atoms, lower alkyl, nitro, amino, lower alkylthio or lower alkoxy radicals or R6 and R7 together represent an optionally unsaturated trimethylene chain; and the pharmacologically acceptable salts thereof. The present invention also provides processes for the preparation of these compounds, as well as pharmaceutical compositions containing them.
408114
Michel Helmut
Roesch Egon
Strein Klaus
Weckerle Wolfgang
Wiedemann Fritz
Boehringer Mannheim G.m.b.h.
Marcoux & Sher Swabey Mitchell Houle
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