Heteroatomic oligonucleoside linkages

Details Heteroatomic oligonucleoside linkages Heteroatomic oligonucleoside linkages

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/706 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07F 7/18 (2006.01) C07H 19/00 (2006.01) C07H 19/04 (2006.01) C07H 19/06 (2006.01) C07H 19/10 (2006.01) C07H 19/16 (2006.01) C07H 23/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2138770

Oligonucleotide-mimicking macromolecules that have improved nuclease resistance are provided. Replacement of the nor- mal phosphorodiester inter-sugar linkages found in natural oligonucleotides with three or four atom linking groups provide un- ique oligonucleotide-mimicking macromolecules that are useful in regulating RNA expression and in therapeutics. Methods of synthesis and use also are disclosed.

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