Heteroatoms-containing tricyclic compounds

Details Heteroatoms-containing tricyclic compounds Heteroatoms-containing tricyclic compounds

C - Chemistry, Metallurgy

07

H

167/125, 167/202

C07H 17/02 (2006.01) A61K 31/70 (2006.01) C07D 498/18 (2006.01) C07H 19/01 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2029694

The invention concerns the compounds of formula I (see formula I) wherein the substituents have various significances. They are prepared by several processes including epimerizing replacement, treatment with cyanogen bromide or thiophosgene, treatment with an acid having a non-nucleophilic anion, deprotection and protection. They possess interesting pharmacological activity as antiinflammatory immunosuppressant, antiproliferative and chemotherapeutic drug resistance reversing agents.

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