Heteroatoms-containing tricyclic compounds

Details Heteroatoms-containing tricyclic compounds Heteroatoms-containing tricyclic compounds

C - Chemistry, Metallurgy

07

H

167/125, 167/185

C07H 19/01 (2006.01) A61K 31/70 (2006.01) C07D 498/08 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2032159

900-9569 A B S T R A C T: HETEROATOMS-CONTAINING TRICYCLIC COMPOUNDS The compounds of formula I Image I wherein the substituents have various significances, possess pharmacological, particularly antiinflammatory and immunosuppressant activity. They can be prepared by one or more of the following process variants: reduction, deprotection, acylation, reaction with N,N'-carbonyl- or N,N'-thiocarbonyldiimidazole, halogenation, splitting off of hydrogen halide, reaction with a hydrogen carbonate, radical deoxygenation, dehydration or reaction with diazomethane or -ethane, optionally under transient protection of reactive groups which it is not desired to react.

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