Heterobicyclic compounds

Details Heterobicyclic compounds Heterobicyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/35 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/675 (2006.01) C07D 307/79 (2006.01) C07D 307/80 (2006.01) C07D 311/22 (2006.01) C07D 311/30 (2006.01) C07D 311/32 (2006.01) C07D 311/60 (2006.01) C07D 335/06 (2006.01) C07D 401/12 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 409/00 (2006.01) C07D 409/04 (2006.01) C07F 9/547 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2090156

-189- ABSTRACT Heterobicyclic Compounds There are disclosed compounds of the general formula Image The heteroatom X is preferably oxygen, but may have other values. The group W is preferably a carbonyl group, but may have other values. The preferred heterocyclic ring is thus a 4-oxo-4H-1-benzopyran ring. This may have a wide range of R2, R3, R6 and R7 substituents. Y is a linking group, chosen from a wide range, but including -COO- , -CONH- , -O- , -SO2- and -SO2NH-. Z is an alkylene chain, and B is a complex amine. These compounds and their prodrugs, enantiomers, diastereoisomers, N-oxides and pharmaceutically acceptable salts are useful for the treatment of hypertension and urinary tract troubles associated with benign prostatic hypertrophy, and for the treatment of other diseases.

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