C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/381 (2006.01) A61P 31/04 (2006.01) C07D 209/42 (2006.01) C07D 333/66 (2006.01) C07D 333/68 (2006.01) C07D 409/12 (2006.01) C07D 491/04 (2006.01) C07D 493/04 (2006.01) C07D 495/10 (2006.01)
Patent
CA 2572750
Described are heterobicyclic compounds such as 4,5,6,7- tetrahydro~benzo[b]thiophene-3-carboxylic acid amides, 4,7-dihydro-5H- thieno[2,3-c]thiopyran~ 3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3- c]pyran-3-carboxylic acid amides, or benzo[b]thiophene-3-carboxylic acid amides and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of various diseases such as infectious diseases, including mycobacteria~induced infections and opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as compositions containing at least one heterobicyclic compound and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the heterobicyclic compound are disclosed.
L'invention concerne des composés hétérobicycliques tels que des amides d'acide 4,5,6,7-tétrahydro-benzo[b]thiophène-3-carboxylique, des amides d'acide 4,7-dihydro-5H-thiéno[2,3-c]thiopyran-3-carboxylique, des amides d'acide 4,7-dihydro-5H-thiéno[2,3-c]pyran-3-carboxylique ou des amides d'acide benzo[b]thiophène-3-carboxylique ainsi que des sels pharmaceutiquement acceptables de ceux-ci, l'utilisation de ces dérivés pour la prophylaxie et/ou le traitement de diverses maladies telles que des maladies infectieuses, notamment des infections dues à des mycobactéries et des maladies opportunistes, des maladies du prion, des maladies immunologiques, des maladies autoimmunes, des troubles bipolaires et cliniques, des maladies cardiovasculaires, des maladies proliférantes cellulaires, le diabète, l'inflammation, des rejets de transplantation, la dysérection, des maladies neurodégénératives, et l'accident cérébrovasculaire, ainsi que des compositions contenant au moins un composé hétérobicyclique et/ou des sels pharmaceutiquement acceptables de celui-ci. En outre, l'invention concerne des procédures de réaction pour la synthèse de ce composé hétérobicyclique.
Backes Alexander
Banhegyi Peter
Engkvist Ola
Felber Beatrice
Freisleben Achim
Borden Ladner Gervais Llp
Gpc Biotech Ag
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