C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61K 31/5025 (2006.01) A61P 19/00 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2618614
Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
La présente invention se rapporte aux composés décrits par la formule chimique (I) ou aux sels pharmaceutiquement acceptables de celle-ci : (I) sont les inhibiteurs de p38 et sont utiles dans le traitement de l~inflammation comme dans le traitement de la polyarthrite rhumatoïde, la spondylarthrite ankylosante, l~arthrite goutteuse et les autres pathologies cliniques arthritiques ; les inflammations articulaires, l~eczéma, le psoriasis ou d~autres pathologies cliniques inflammatoires de la peau tels que l~érythème solaire ; les pathologies cliniques inflammatoires des yeux notamment la conjonctivite ; le pyrésis, la douleur et autres pathologies cliniques associées à l~inflammation.
Chen Meng-Hsin
Doherty James B.
Li Zhen
Natarajan Swaminathan R.
Sahoo Soumya P.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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