C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2670042
The present invention relates generally to amide containing heterobicyclic containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-3 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13 and MMP-3 inhibitors.
La présente invention concerne de manière générale des agents pharmaceutiques contenant une matrice hétérobicyclique contenant un amide, et en particulier des composés inhibiteurs de métalloprotéase hétérobicycliques contenant un amide. Plus particulièrement, l'invention propose une nouvelle catégorie de composés inhibiteurs de MMP-3 et/ou MMP-13 hétérobicycliques, qui présentent une valeur et sélectivité accrues par rapport aux inhibiteurs de MMP-13 et MMP-3 actuellement connus.
Bluhm Harald
Essers Michael
Gege Christian
Hochguertel Matthias
Kroth Heiko
Alantos Pharmaceuticals Holding Inc.
Gowling Lafleur Henderson Llp
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