C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 19/02 (2006.01)
Patent
CA 2653131
The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP- 13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP- 13 and MMP-3 inhibitors.
La présente invention concerne globalement des agents pharmaceutiques contenant un amide et, en particulier, des composés inhibiteurs de métalloprotéases hétérobicycliques contenant un amide. La présente invention concerne plus précisément une nouvelle classe de composés inhibiteurs de MMP-3 ou de MMP-13 hétérobicycliques, présentant un pouvoir supérieur par rapport aux inhibiteurs de MMP-3 et de MMP-13 actuellement connus.
Arndt Torsten
Biesinger Ralf
Bluhm Harald
Deng Hongbo
Essers Michael
Alantos Pharmaceuticals Inc.
Alantos Pharmaceuticals Holding Inc.
Gowling Lafleur Henderson Llp
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