Heterobifunctional antibodies possessing dual catalytic and...

Details Heterobifunctional antibodies possessing dual catalytic and... Heterobifunctional antibodies possessing dual catalytic and...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/42 (2006.01) C07K 16/44 (2006.01) C07K 16/46 (2006.01) C12N 5/12 (2006.01) C12N 9/00 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2067919

A novel and useful class of antibody molecules is described which possess the characteristics of an antigen- specific antibody and a catalytic antibody. Such a hybrid molecule may be assembled in vitro using biochemical means or using in vivo methods including cell hybridization, or recombinant DNA technologies. The product of the invention possesses both antigen target specificity as well as an intrinsic catalytic activity. Further said product may be used in any appropriate application including diagnostic test as a substitute for an enzyme-labelled antibody conjugate or as a therapeutic reagent whereby a part of the antibody molecule recognizes a unique cellular marker and the catalytic portion of antibody molecule has therepeutic activity.

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