A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7034 (2006.01) A61P 35/00 (2006.01) C07H 15/207 (2006.01)
Patent
CA 2760292
Compounds, compositions and methods are provided for treating cancer and inflammatory diseases, and for releasing cells such as stem cells (e.g., bone marrow progenitor cells) into circulating blood and enhancing retention of the cells in the blood. More specifically, heterobifunctional compounds that inhibit both E-selectins and CXCR4 chemokine receptors are described.
L'invention porte sur des composés, des compositions et des procédés pour traiter le cancer et des maladies inflammatoires, et pour libérer des cellules telles que des cellules souches (par exemple des cellules progénitrices de moelle osseuse) dans la circulation sanguine et augmenter la rétention des cellules dans le sang. De façon plus spécifique, l'invention porte sur des composés hétérobifonctionnels qui inhibent à la fois les E-sélectines et les récepteurs aux chimiokines CXCR4.
Magnani John L.
Sarkar Arun K.
Glycomimetics Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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