Heterobifunctional pan-selectin inhibitors

Details Heterobifunctional pan-selectin inhibitors Heterobifunctional pan-selectin inhibitors

C - Chemistry, Metallurgy

07

H

C07H 15/22 (2006.01) A61K 31/7056 (2006.01) A61K 31/7072 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2670130

Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).

L'invention concerne des composés et des procédés destinés à moduler des processus in vitro et in vivo occasionnés par une liaison sélectine. L'invention concerne, plus spécifiquement des modulateurs de sélectine et leur utilisation. Ces modulateurs de sélectine qui modulent (par exemple, inhibent ou améliorent) une fonction d'origine sélectine, comprennent des glycomimétiques particuliers, seuls ou liés à un élément d'une classe de composés désignée par BASA (acides benzyl amino sulfoniques) ou un élément d'une classe de composés désignée par BACA (acides benzyl amino carboxyliques).

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