Heteroclitic analogs and related methods

Details Heteroclitic analogs and related methods Heteroclitic analogs and related methods

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 39/00 (2006.01) C07K 1/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 14/74 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2481462

Heteroclitic analogs of class I epitopes are prepared by providing convervative, semi-conservative, or non-conservative amino acid substitutions at positions 3 and/or 4 and/or 5 and/or 6 and/or 7 and/or 8 and/or 9 and/or 10 of these epitopes. The analogs are useful in eliciting immune responses with respect to the corresponding wild-type epitopes.

L'invention concerne des analogues hétéroclitiques d'épitopes de classe I, préparés par substitutions d'acides aminés conservatrices, semi-conservatrices ou non conservatrices aux positions 3 et/ou 4 et/ou 5 et/ou 6 et/ou 7 et/ou 8 et/or 9 et/ou 10 de ces épitopes. Ces analogues sont utiles pour déclencher des réponses immunitaires par rapport aux épitopes de type sauvage correspondants.

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