Heteroclitic analogs and related methods

Details Heteroclitic analogs and related methods Heteroclitic analogs and related methods

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 39/00 (2006.01) C07K 7/06 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2386341

Heteroclitic analogs of Class I epitopes are prepared by providing conservative or semi-conservative amino acid substitutions at positions 3 and/or 5 and/or 7 of these epitopes. The analogs are useful in eliciting immune responses with respect to the corresponding wildtype epitopes.

La présente invention concerne des analogues hétéroclites d'épitopes Classe I que l'on obtient en réalisant des substitutions acide aminé conservatoires ou semi-conservatoires aux positions 3 et/ou 5 et/ou 7 de ces épitopes. Ces analogues conviennent particulièrement pour éliciter les réponses immunitaires par rapport aux épitopes de type sauvage correspondant.

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