C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61K 31/4745 (2006.01) A61P 1/02 (2006.01) A61P 1/04 (2006.01) A61P 1/16 (2006.01) A61P 1/18 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 5/00 (2006.01) A61P 5/14 (2006.01) A61P 5/38 (2006.01) A61P 7/00 (2006.01) A61P 7/02 (2006.01) A61P 7/04 (2006.01) A61P 7/06 (2006.01) A61P 9/00 (2006.01) A61P 9/04 (2006.01) A61P 9/06 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 13/08 (2006.01) A61P 13/10 (2006.01)
Patent
CA 2622605
Disclosed is a novel compound which has a pyrazolonaphthyridine or pyrazoloquinoline skeleton, which shows an inhibitory effect on phosphodiesterase IV. In the compound, an organic group (e.g., a homocarbocyclic ring is bound to bound particularly to position 3 of a specific heterocyclic skeleton through an alkylene group, and a homocarbocyclic ring is bound particularly to position 5 of the heterocyclic skeleton. In the compound, at least one of the ring (the homocarbocyclic ring or heterocyclic ring) bound to position 3 of the pyrazolonaphthyridine skeleton and the homocarbocyclic ring bound to position 5 of the pyrazolonaphthyridine may have an alkyl halide group and/or an alkoxy halide group as a substituent. The compound or a salt thereof is useful as a phosphodiesterase IV inhibitor and shows a high inhibitory effect on phosphodiesterase IV.
L'invention concerne un nouveau composé qui a un squelette de pyrazolonaphtyridine ou de pyrazoloquinoléine, lequel présente un effet d'inhibition sur la phosphodiestérase IV. Dans le composé, un groupe organique (par exemple un cycle homocarbocyclique) est obligé de se lier en particulier à la position 3 d'un squelette hétérocyclique spécifique via un groupe alkylène et un cycle homocarbocyclique est lié en particulier à la position 5 du squelette hétérocyclique. Dans le composé, au moins l'un du cycle (le cycle homocarbocyclique ou le cycle hétérocyclique) lié à la position 3 du squelette pyrazolonaphtyridine et du cycle homocarbocyclique lié à la position 5 du cycle pyrazolonaphtyridine peut avoir un groupe halogénure d'alkyle et/ou un groupe halogénure d'alcoxy comme substituant. Le composé ou un sel de celui-ci est utile comme inhibiteur de la phosphodiestérase IV et présente un effet d'inhibition élevé sur la phosphodiestérase IV.
Aotsuka Tomoji
Ishitani Kouki
Kanazawa Hashime
Kumazawa Kentarou
Nose Takashi
Aska Pharmaceutical Co. Ltd.
Fetherstonhaugh & Co.
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