Heterocycle derivatives which inhibit factor xa

Details Heterocycle derivatives which inhibit factor xa Heterocycle derivatives which inhibit factor xa

C - Chemistry, Metallurgy

07

D

C07D 239/26 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) C07D 213/56 (2006.01) C07D 213/61 (2006.01) C07D 213/73 (2006.01) C07D 213/84 (2006.01) C07D 213/89 (2006.01) C07D 237/08 (2006.01) C07D 403/10 (2006.01)

Patent

CA 2266890

The invention relates to heterocyclic derivatives of the formula (I): A-B-X1- T1(R2)-L1-T2(R3)-X2-Q or pharmaceutically acceptable salts thereof, which possess antithrombotic and anticoagulant properties due to their inhibition of Factor Xa and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the heterocyclic derivatives, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect.

L'invention concerne des dérivés hétérocycliques de la formule (I): A-B-X?1¿-T?1¿(R?2¿)-L?1¿-T?2¿(R?3¿)-X?2¿-Q ou des sels pharmaceutiquement acceptables les renfermant qui, grâce à leur action inhibitrice du Facteur Xa, présentent des propriétés antithrombotiques et anticoagulantes, et qui sont, dès lors, utiles dans des procédés de traitement destinés aux humains ou aux animaux. L'invention concerne également des procédés de préparation des dérivés hétérocycliques, des compositions pharmaceutiques les renfermant, ainsi que leur utilisation dans la fabrication de médicaments utilisés en vue de produire un effet antithrombotique ou anticoagulant.

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