C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/381 (2006.01) A61K 31/405 (2006.01) A61K 31/427 (2006.01) A61K 31/443 (2006.01) A61K 31/4439 (2006.01) A61K 31/53 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/10 (2006.01) C07D 403/14 (2006.01) C07D 405/10 (2006.01) C07D 405/12 (2006.01) C07D 409/10 (2006.01) C07D 417/10 (2006.01)
Patent
CA 2588766
The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
La présente invention concerne des composés et sels pharmaceutiquement admis représentés par la formule (I). Ces produits conviennent au traitement de troubles du métabolismes en lien avec les résistances à l'insuline ou à la leptine ou avec l'hyperglycémie. Ces composés, qui sont essentiellement des inhibiteurs des PTP (Protein Tyrosine Phosphatases), et notamment de la PTP-1B, s'adressent au traitement du diabète et d'autres maladies médiées par les PTP telles que les cancers, les maladies neurodégénératives et analogues. L'invention concerne également des compositions pharmaceutiques reprenant les composés de l'invention, ainsi que, contre ces états, des traitements à base de ces composés.
Combs Kerry
Hu Shaojing
Van Zandt Michael C.
Whitehouse Darren
Osler Hoskin & Harcourt Llp
The Institutes For Pharmaceutical Discovery Llc
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