C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/54 (2006.01) A61K 31/4164 (2006.01) A61K 31/4439 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2633351
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts and tautomers thereof. Compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative diseases, including cancer. They are also useful for treating neurodegenerative diseases, mental retardation, schizophrenia, inflammatory diseases, restenosis, immune disorders, diabetes, cardiovascular disorders and asthma.
La présente invention a pour objet des composés de formule (I), et des sels pharmaceutiquement acceptables et des tautomères de ceux-ci. Les composés de la présente invention sont inhibiteurs de l'histone désacétylase (HDAC) et sont utiles pour traiter des maladies prolifératives cellulaires, y compris le cancer. Ils sont aussi utiles pour traiter des maladies neurodégénératives, un retard mental, la schizophrénie, des maladies inflammatoires, une resténose, des troubles de l'immunisation, le diabète, des troubles cardio-vasculaires et l'asthme.
Ingenito Raffaele
Jones Philip
Ontoria Ontoria Jesus Maria
Scarpelli Rita
Schultz-Fademrecht Carsten
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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