Heterocyclecarbonylmethyl amine intermediates

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 207/12 (2006.01) C07D 205/04 (2006.01) C07D 207/24 (2006.01) C07D 209/42 (2006.01) C07D 211/42 (2006.01) C07D 211/46 (2006.01) C07D 235/24 (2006.01) C07D 261/02 (2006.01) C07D 263/06 (2006.01) C07D 265/02 (2006.01) C07D 275/02 (2006.01) C07D 277/04 (2006.01) C07D 277/14 (2006.01) C07D 277/34 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2342471

Disclosed are novel amine compounds of the Formula: (see formula I) (wherein R5 is H; R4 is H or optionally F -substituted phenylmethyl, thienylmethyl or furylmethyl; and R12 is an optionally substituted ring selected from the group consisting of thiazolidin-3-yl, 1-oxothiazolidin-3-yl, 1,1- dioxothiazolidin-3-yl, pyrrolidin-1-yl, piperidin-1-yl, azetidin-1-yl, 1,2-oxazinan-2-yl, isoxazolidin-2-yl, isothiazolidin-2-yl, 1,2-oxazetidin-2-yl and oxazolidin-3-yl. The amine compounds are useful for producing compounds of the formula: (see formula II) (wherein R1, R10 and R11 are H or substituent; R2 is H, R3 is H or alkyl; R6 corresponds to CO-R12; and R4 and R5 are as defined above) which are glycogen phosphorylase inhibitors.

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