Heterocycles

Details Heterocycles Heterocycles

C - Chemistry, Metallurgy

07

D

167/211, 260/251

C07D 405/12 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01)

Patent

CA 2009902

The invention concerns a heterocycle of the formula Image wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms; A is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene; X is oxy, thio, sulphinyl, sulphonyl or amino; Ar is phenylene which may optionally bear one or two substituents or Ar is an optionally substituted 6-membered heterocyclene moiety containing up to three nitrogen atoms; R1 is hydrogen, (1-6C) alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; and R2 and R3 together form a group of the formula -A2-X2-A3- which, together with the carbon atom to which A2 and A3 are attached, defines a ring having 4 to 7 ring atoms, wherein A2 and A3, which may be the same or different, each is (1-4C) alkylene and X2 is oxy, thio, sulphinyl, sulphonyl or amino; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.

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