Heterocycles as inhibitors of leucocyte adhesion and as...

C - Chemistry – Metallurgy – 07 – K

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07K 5/072 (2006.01) A61K 31/415 (2006.01) A61K 31/675 (2006.01) A61K 38/05 (2006.01) C07D 233/76 (2006.01) C07D 403/10 (2006.01) C07F 9/6506 (2006.01) C07K 5/02 (2006.01) C07K 5/117 (2006.01)

Patent

CA 2220822

Heterocycles as inhibitors of leucocyte adhesion and as VLA4 antagonists Compounds of the formula I Image in which B,D,E,R,W,Y,Z,b,c,d,e,f,g and have the meanings indicated in the claims, are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 which belongs to the group of integrins. The invention relates to the use of compounds of the formula I, and of pharmaceutical preparations which contain such compounds, for the treatment and prophylaxis of diseases which are caused by an undesired extent of leucocyte adhesion and/or leucocyte migration or which are associated therewith or in which cell-cell or cell- matrix interactions play a part which are based on interactions of VLA-4 receptors with their ligands, for example of inflammatory processes, rheumatoid arthritis or allergic disorders, and it also relates to the use of compounds of the formula I for the production of pharmaceuticals for use in such diseases. It further relates to novel compounds of the formula I.

Hétérocycles, inhibiteurs de l'adhérence des leucocytes et antagonistes des récepteurs VLA-4. Composés de formule I Image , dans laquelle B, D, E, R, W, Y, Z, b, c, d, e, f et g ont la signification donnée dans les revendications, inhibiteurs de l'adhérence et de la migration des leucocytes et (ou) antagonistes des récepteurs VLA-4 d'adhérence, appartenant au groupe des intégrines. L'invention porte sur l'emploi de composés de formule I et de préparations pharmaceutiques à base de ces composés, pour le traitement et la prévention de maladies causées par un degré indésirable d'adhérence et (ou) de migration des leucocytes, ou encore associées à ces processus ou dans lesquelles les interactions cellules-cellules ou cellules-substrat basées sur des interactions des récepteurs VLA-4 avec leurs ligands jouent un certain rôle, notamment dans les affections inflammatoires, la polyarthrite rhumatoïde et les troubles allergiques; le brevet porte également sur l'emploi des composés de formule I pour la fabrication de produits pharmaceutiques, destinés à ces maladies. Enfin il porte sur de nouveaux composés de formule I.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Heterocycles as inhibitors of leucocyte adhesion and as... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heterocycles as inhibitors of leucocyte adhesion and as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocycles as inhibitors of leucocyte adhesion and as... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1976884

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.