Heterocycles as potassium channel modulators

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/04 (2006.01) A61K 31/437 (2006.01) A61K 31/5025 (2006.01) A61K 31/519 (2006.01) A61P 25/00 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2696631

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides heterocycles, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, seizure, retinal degeneration, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety, neuronal degeneration and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.

L'invention concerne des composés, compositions et procédés qui sont utiles dans le traitement de maladies par la modulation du flux d'ions potassiques à travers les canaux potassiques sensibles au voltage. Plus particulièrement, l'invention propose des hétérocycles, compositions et procédés qui sont utiles dans le traitement des troubles du système nerveux central ou périphériques (par exemple, la migraine, l'ataxie, la maladie de Parkinson, les troubles bipolaires, la névralgie faciale, la spasticité, les troubles de l'humeur, les tumeurs du cerveau, les troubles psychotiques, la myokimie, les crises, l'épilepsie, la dégénérescence rétinienne, la perte auditive et de la vision, la maladie d'Alzheimer, la perte de mémoire liée à l'âge, les déficiences de l'apprentissage, l'anxiété, la dégénérescence neuronale et les maladies de neurone moteur, le maintien du contrôle de la vessie ou le traitement d'une incontinence urinaire) et en tant qu'agents neuroprotecteurs (par exemple pour empêcher un accident cérébral et similaires) en modulant les canaux potassiques associés au départ ou à la récurrence des affections indiquées.

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