Heterocycles that are inhibitors of impdh enzyme

Details Heterocycles that are inhibitors of impdh enzyme Heterocycles that are inhibitors of impdh enzyme

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/33 (2006.01) A61P 43/00 (2006.01) C07D 215/48 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2407370

Compounds of formula (I) wherein X1 is C(O), -S(O)-, or -S(O)2-; X2 is CR3 or N; X3 is -NH-, -O-, or -S-; X4 is CR4 or N; X5 is CR5 or N; and X6 is CR6 or N are useful as inhibitors of IMPDH enzyme. Thus, these compounds can be used as therapeutic agents for IMPDH- associated disorders.

La présente invention concerne des composés de formule (I) dans laquelle X?1¿ représente C(O), -S(O)-, ou -S(O)¿2?-; X?2¿ représente CR?3¿ ou N; X?3¿ représente -NH-, -O-, ou -S-; X?4¿ représente CR?4¿ ou N; X?5¿ représente CR?5¿ ou N; et X?6¿ représente CR?6¿ ou N. Ces composés sont utiles en tant qu'inhibiteurs de l'enzyme IMPDH, par conséquent on peut utiliser lesdits composés en tant qu'agents thérapeutiques pour les maladies associées à l'enzyme IMPDH.

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