Heterocyclic acyl aminodiol .beta.-amino acid derivatives

Details Heterocyclic acyl aminodiol .beta.-amino acid derivatives Heterocyclic acyl aminodiol .beta.-amino acid derivatives

C - Chemistry, Metallurgy

07

C

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C07C 237/22 (2006.01) A61K 31/16 (2006.01) A61K 31/33 (2006.01) C07D 209/18 (2006.01) C07D 209/20 (2006.01) C07D 209/42 (2006.01) C07D 215/48 (2006.01) C07D 241/44 (2006.01) C07D 307/81 (2006.01) C07D 307/85 (2006.01) C07D 311/22 (2006.01) C07D 311/24 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2031446

Case 2585 Heterocyclic Acyl Aminodiol .beta.-Amino Acid Derivatives ABSTRACT Non-peptidyl compounds characterized generally as heterocyclic acyl aminodiol .beta.-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are compounds of the formula Image wherein R1 is selected from aryl and aralkyl groups represented by Image and wherein R1 may be further selected from heteroaryl and heteroaralkyl represented by Image Image wherein each of T and A is independently selected from N and CH; wherein n is a number selected from zero through five, inclusive; wherein X is selected from oxygen atom, methylamino and NH; wherein each of Y and Z is independently selected from chloro, fluoro, methoxy and dimethylamino; wherein Q is oxygen atom; and wherein each of T and A is independently selected from N and CH; wherein each of R2 and R4 is independently selected from hydrido and methyl; wherein R3 is selected from methyl and ethyl; wherein R5 is cyclohexylmethyl; wherein R6 is hydroxy; wherein R7 is selected from isobutyl and ethyl; wherein each of R8 and R9 is independently selected from hydrido, methyl and isopropyl; or a pharmaceutically-acceptable salt thereof.

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