Heterocyclic amide compounds and pharmaceutical use thereof

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 239/47 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 213/72 (2006.01) C07D 213/73 (2006.01) C07D 213/75 (2006.01) C07D 239/46 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01)

Patent

CA 2219364

Heterocyclic compounds represented by general formula (I) or pharmacologically acceptable salts of the same and a medicinal composition comprising the same, wherein each symbol has the meaning as defined in the specification. The heterocyclic amide compounds and pharmacologically acceptable salt thereof have excellent effects of inhibiting chymases on mammals including human being and can be orally or parenterally administered. Thus they are useful as a chymase inhibitor and can be used in the prevention and treatment of various diseases caused by chymases such as those caused by angiotensin II.

La présente invention concerne des composés hétérocycliques représentés par la formule générale (I) ou certains de leurs sels acceptables en pharmacologie. L'invention concerne également une composition médicinale comprenant ces composés. La signification des symboles de la formule générale est donnée dans la description de l'invention. Faisant preuve d'une bonne activité d'inhibition des chymases chez les mammifères, y compris chez l'homme, et pouvant s'administrer par voie orale ou parentérale, ces composés hétérocycliques et leurs sels acceptables en pharmacologie présentent un intérêt comme inhibiteurs des chymases et conviennent particulièrement au traitement préventif et curatif de diverses affections imputables aux chymases, et notamment de celles qui sont imputables à l'angiotensine II.

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