Heterocyclic amide compounds as cell adhesion inhibitors

Details Heterocyclic amide compounds as cell adhesion inhibitors Heterocyclic amide compounds as cell adhesion inhibitors

C - Chemistry, Metallurgy

07

K

C07K 5/078 (2006.01) A61K 31/401 (2006.01) A61K 31/472 (2006.01) A61K 38/05 (2006.01) C07D 207/48 (2006.01) C07D 211/96 (2006.01) C07D 217/26 (2006.01) C07K 5/06 (2006.01)

Patent

CA 2291778

Compounds of formula (I) are antagonists of VLA-4 and/or .alpha.4.beta.7, and as such are useful in the inhibition or prevention of cell adhesion and cell- adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.

Des composés de formule (I) sont des antagonistes de VLA-4 et/ou de .alpha.¿4?.beta.¿7? et sont, en tant que tels, utiles pour inhiber ou empêcher l'adhésion cellulaire et pour lutter contre des pathologies induites par l'adhésion cellulaire. Ces composés peuvent être formulés sous forme de compositions pharmaceutiques et sont adaptés pour être utilisés dans le traitement de l'asthme, des allergies, des inflammations, de la sclérose en plaques et d'autres maladies inflammatoires et auto-immunes.

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