Heterocyclic amide derivatives as calcium channel blockers

Details Heterocyclic amide derivatives as calcium channel blockers Heterocyclic amide derivatives as calcium channel blockers

C - Chemistry, Metallurgy

07

D

C07D 295/185 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2633457

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type or T-type calcium channel activity are disclosed. Specifically, a series of heterocyclic amides are disclosed of the general formula (I) where Z is N or CHNR2 and X is NR2, O, S, S=O or SO2. Among other definitions for R, R1, W and Y, the compounds of formula (1) are further characterized by at least one of W or Y being CR3Ar2 where Ar is an aromatic or heteroaromatic ring

La présente invention concerne des procédés et des composés efficaces pour le traitement de pathologies caractérisées par une activité de canal calcique indésirable, en particulier une activité de canal calcique de type N ou de type T. Spécifiquement, la présente invention concerne une série d'amides hétérocycliques de formule générale (I) où Z est N ou CHNR<SUP>2</SUP> et X est NR<SUP>2</SUP>, O, S, S=O ou SO<SUB>2</SUB>. Entre autres définitions pour R, R<SUP>1</SUP>, W et Y, les composés de formule (1) sont caractérisés plus avant en ce qu'au moins un parmi W ou Y est CR<SUP>3</SUP>Ar<SUB>2</SUB> où Ar est un cycle aromatique ou hétéroaromatique (par exemple, où W ou Y est un fragment benzhydryle).

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