Heterocyclic amide derivatives as cytokine inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 333/70 (2006.01) A61K 31/343 (2006.01) A61K 31/381 (2006.01) A61K 31/404 (2006.01) A61P 29/00 (2006.01) C07C 311/08 (2006.01) C07D 209/42 (2006.01) C07D 307/85 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2478232

Disclosed are amide compounds of formula (I) wherein Ar1, Q, Y and R3-R6 of formula (I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

L'invention concerne des composés d'amides de formule (I), dans laquelle Ar?1¿, Q, Y et R?3¿-R?6¿ sont définis. Lesdits composés inhibent la production de cytokines impliquées dans des processus inflammatoires et sont utilisés pour traiter des maladies et des états pathologiques entraînant une inflammation tels qu'une maladie inflammatoire chronique. L'invention concerne également des procédés de préparation desdits composés et des compositions pharmaceutiques comprenant lesdits composés.

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