C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/10 (2006.01) A61K 31/427 (2006.01) A61K 31/4709 (2006.01) A61K 31/498 (2006.01) C07D 277/20 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2478342
The present invention relates to certain substituted heterocycles of Formula (200), wherein B, H, I, J and K together with the Ar5 form a ring containing at least one amide residue, and W, X, Y and Z together form a 2,4- thiazolidinedione, 2-thioxothiazolidine-4-one, 2,4-imidazolidinedione or 2- thioxo-imidazolidine-4-one residue; or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment of diseases such as type 2 diabetes, and related disorders of lipid and carbohydrate metabolism, including atherosclerosis. The compounds are also useful for treating diseases of uncontrolled proliferation, such as cancers in general, including breast cancer.
L'invention concerne certains hétérocycles substitués représentés par la formule (200). Dans cette formule, B, H, I, J et K forment avec Ar¿5? un anneau contenant au moins un résidu amide, et W, X, Y et Z forment ensemble un résidu de 2,4-thiazolidinédione, 2-thioxothiazolidine-4-one, 2,4-imidazolidinédione ou 2-thioxo-imidazolidine-4-one; ou un sel de ceux-ci acceptable sur le plan pharmaceutique. Ces composés sont utiles dans le traitement de maladies telles que le diabète de type 2 et des troubles relatifs au métabolisme lipidique et des glucides, tels que l'athérosclérose. Ils sont également utiles dans le traitement de maladies à prolifération non contrôlée, telles que des cancers en général, notamment le cancer du sein.
Al-Shamma Hussien A.
Boudjelal Mohamed
Giachino Andrea Fanjul
Guo Jianhua
Jakubowicz-Jaillardon Karine
Incyte San Diego Incorporated
Mbm Intellectual Property Law Llp
Ortho Mcneil Pharmaceutical Inc.
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